MW 467.9 Da, Purity >97%. Irreversible EGFR inhibitor (IC₅₀ = 38.5 nM). Greater inhibitory activity against EGFR then erbB-2, Src, Cdk4, c-Met, Raf, MEK/ERK (IC₅₀ values are 1255, 282, >20,000, 4100, 3353 and 800 nM respectively). Active in vivo. .
The product is subject to the following: Abcam Restricted Use Statement